Our laboratory investigates the cellular DNA damage response.
This research stems from our interest in the human genetic disorder Ataxia-Telangiectasia (A-T), in which a central axis of the DNA damage response is missing.
Maintenance of genomic stability is essential for cellular function and prevention of undue cell death or cancer.
However, understanding the DNA damage response is essential for refining cancer treatment modalities.
The DNA damage response is a complex network of processes and pathways that are activated immediately following damage to the DNA, particularly double-strand breaks.
Genetic defects in the DNA damage response lead to genome instability syndromes, which typically include tissue degeneration, cancer predisposition, and sensitivity to specific DNA damaging agents.
A-T is an example for a prototype genomic instability syndrome.
In 1995 we identified the responsible gene and called it ATM (A-T, Mutated). Since then we have been studying the activity of its product, the ATM protein, which turned out to be a master controller of the DNA damage response.
We investigate this system with cell biology methods, gene targeting in mice, and system’ biology strategies including high-throughput screens, advanced proteomics and bioinformatics.
Prof. Yosef Shiloh, PhD
Sackler Faculty of Medicine