Prof. Arbesfeld’s laboratory has a longstanding interest in the molecular events that lead to the development and progression of Colorectal Cancer (CRC) one of the leading causes of cancer related morbidity and mortality. The research team focus on the Wnt signaling pathway that controls normal development and is involved in many types of malignant transformation especially in CRC development. The research aims to decipher the molecular functions of individual Wnt signaling components such as APC and β-catenin and their expression patterns, cellular localization, and interactions using next generation sequencing, cell-biology, and biochemical approaches, as well as different mice models. We currently lead a clinical trial aimed at resorting the function of APC in polyposis patients. Ultimately, the aim is to use Wnt signaling components as therapeutic targets in cancer.
Prof. Rina Arbesfeld PhD
Sackler Faculty of Medicine