Stopping the spread of breast cancer. One in eight women worldwide are diagnosed with breast cancer. Early detection, while increasingly common, is not sufficient in preventing metastasis. Prof. Shomron’s lab at the TAU Sackler Faculty of Medicine, aims to block a cancer cell's ability to change shape and move. The scientific team, including Dr Avital Gilam, Dr Daphna Weissglas, Dr Nir Pillar and Avital Polsky, looked at mutations and polymorphisms that other researchers have ignored and by doing so, we were able to identify novel genes that can stop the movement of the primary tumor in mice. MicroRNAs targeted at one of these genes via a nanoparticle based delivery vehicle, markedly suppressed metastasis in a breast cancer mouse model.
This work indicated that breast cancer could be regulated in its initial stages. This study was reported in Nature Communications in September 2016
Prof. Noam Shomron PhD
Sackler Faculty of Medicine