The research team looks at the genetic background of colorectal cancer and other GI tumors.
The aim is to identify novel genes and mutations that are related to GI cancers in families and individuals, by novel and advanced genetic technologies as Next Generation Sequencing and whole exome analysis. We study hereditary syndromes that are related to GI neoplasia. In particular, we focus on APC gene, its mutation profile, second hits and novel potential therapeutic approaches like read through of nonsense stop mutation by macrolide antibiotics. We also look at metabolic and environmental factors related to colorectal cancer like nutrition and advanced glycation products.
Main Research topics include:
• Novel mutations and variants and founder mutations related to hereditary GI cancers in Israel
• Microbiome in patients with hereditary GI cancer and polyposis
• Second hits in APC gene
• POL gene mutation characterization in colonic neoplasia
• APC read through in FAP patients with nonsense stop codon mutations by macrolide antibiotics
• RAGE and AGES in colorectal neoplasia (ELIZA, IHC) and heir relation to metabolic and nutritional profile
Prof. Rina Arbesfeld- Tel Aviv University, Dr Karina Yaniv- Weizmann Inst, Dr Leon Raskin
Vanderbilt University USA
Revital Kariv, MD
Tel-Aviv Sourasky Medical Center