As a clinician-investigator and a practicing medical oncologist, Dr. Leibowitz is engaged in basic, translational and clinical cancer research.
Since 2008, the lab at the cancer research center at the 'Sheba' campus has been studying the role of micro-RNAs in solid malignancies, and was the first to identify the large micro-RNA cluster that is silenced in melanoma. This cluster was later dubbed 'the larger tumor suppressor miRNA cluster' and was shown to be down-regulated in a wide range of malignancies. Dr. Leibowitz team showed the involvement of three miRNAs from this cluster in melanoma progression, and continue to study the role of this cluster in the pathogenesis of this disease and in determining the 'stemness potential' of cancer cells. In parallel, the team studies the involvement of micro-RNAs in regulation of immune checkpoint genes at the 'immunological synapse' in both melanoma and bladder cancer. The group continues to study the cross talk between miRNAs, checkpoint mRNA expression and immunogenicity of solid malignancies.
Dr. Raya Leibowitz, MD, PhD
Sheba Medical Center