Dr. Michael Milyavsky

Milyavsky lab at the Department of Pathology, Sackler Faculty of Medicine investigates how normal and Leukemic Stem Cells (LSCs) cope with stress, e.g. DNA damage, transplantation and aging. These questions are important to preserve normal blood regeneration and to limit the risk of leukemogenesis. In addition, we strive to discover how LSCs escape therapy and try to devise strategies to prevent this from happening. 
To address these questions, we study DNA damage signaling and its outcomes in highly purified human normal and leukemia cell subsets. We collaborate with Dr. L. Wiesmuller, Ulm University, Germany.
In addition, we developed the first fluorescent reporter that can depict the stemness-state of a given leukemia cell.  This novel and versatile research tool provides the platform to identify compounds with selective toxicity towards “stemness” enriched leukemia state via high-throughput chemical screening. We collaborate with hemato-oncologists Dr. A. Nagler and Dr. Canaani from Sheba Medical center on isolation, characterization and targeting of leukemia stem cells based on this stemness reporter. 
We hope that targeting LSC via selective inhibition of their aberrant stemness transcriptional circuit is the prerequisite for leukemia cure.

Contact info:

Michael Milyavsky, Ph.D
Sackler Faculty of Medicine
mmilyavsky@post.tau.ac.il

https://www.milyavskylab.com/

 

 

 

 

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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