Tumor-Microenvironment Cellular Interactions in Cancer Progression and Metastasis
As part of the surgical oncology research unit, Dr. Lahat’s lab conducts patient-driven translational research, studying the molecular basis of various soft tissue sarcoma (STS) tumors, and gastrointestinal malignancies. The research led by Dr. Loewenstein, focuses on tumor microenvironment cellular interactions in cancer progression and metastasis.
The aim is to explore distinct signaling pathways and molecules that may play a role in cancer progression and metastasis. Specifically, the crosstalk between metastatic GI cancer cells and the omentum mediated by extracellular vesicles and exosomes in the context of peritoneal metastasis. We also investigate the potential role of miRNAs as molecular biomarkers for staging, prognosis, and pattern of future spread. For these purposes we frequently utilize in-vitro and in-vivo models, human cancer specimens from our clinically annotated tissue bank, as well as various advanced molecular and bioinformatic approaches.
Collaborates with the following:
Prof. Anat Aharon, Microvesicles Research Laboratory, Rambam Health Care Campus
Dr. Yishai Levin, and Dr. Ravid Straussman, Weizmann Institute of Science
Dr. Metsada Pasmanik-Chor, Bioinformatics Unit, Tel-Aviv University
Prof. Yuman Fong, City of Hope National Medical Center, CA, USA